What drugs are used in indigestion?   The drugs which are commonly prescribed include antacids and prokinetic drugs. Antacids neutralizes acid in the stomach and are frequently prescribed for a variety of stomach complaints. They are effective against heartburn but may be less effective against symptoms caused by a slow digestion. Prokinetic drugs are prescribed to help the "slow" stomach. They restore the stomach to its normal working condition. Prokinetics help the stomach to empty its contents more quickly. They relieve the symptoms of a full and bloated stomach.