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| 1)
Hepatitis |
| a) |
Drug
trials on treatment of patients with chronic hepatitis
B infection and hepatitis B-related cirrhosis. |
| b) |
Association
between HLA haplotypes and the clearance of hepatitis
B virus in chronic hepatitis B carriers. |
| c) |
Epidemiology
of hepatitis G in blood donors and patients with chronic
hepatitis B infection. |
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| 2)
Helicobacter pylori |
| a) |
Role
of Helicobacter pylori in peptic ulcer, gastric
cancer, non-ulcer dyspepsia & gastro-oesophageal reflux
disease. |
| b) |
Drug
trials on eradication of Helicobacter pylori. |
| c) |
Pathogenic
mechanisms of Helicobacter pylori. |
| d) |
Transmission
of Helicobacter pylori. |
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| 3)
Gastro-oesophageal reflux disease and oesophageal motility disorder |
| a) |
Epidemiology
of gastrooesophageal reflux disease. |
| b) |
The
role of manometry, ambulatory pH and motility monitoring
in the investigation of non-cardiac chest pain and dysphagia. |
| c) |
Pathogenesis
of gastrooesophageal reflux disease. |
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| 4)
Gastrointestinal endoscopy |
| a) |
Research
on applications of endoscopy. |
| b) |
Use
of endoscopic ultrasound for gastrointestinal cancer staging. |
| c) |
Use
of chromoendoscopy for classifying colorectal polyps. |
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| 5)
Outcome research in Gastroenterology |
| a) |
Usefulness
of endoscopic ultrasound in decision-making and clinical
algorithms. |
| b) |
Audit
of GI endoscopy - indications, results and outcomes. |
| c) |
Cost-effectiveness
of GI procedures and management algorithms. |
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| 6) Gastrointestinal
motility |
| a) |
Use
of scintigraphic and non-radioactive 13C-labelled methods
to measure gastric emptying. |
| b) |
Barostat
studies. |
| c) |
Chronic
constipaiton: colonic transit measurements, pelvic floor
functions, tissue neuropeptide levels, dietary factors. |
| d) |
Irritable
bowel syndrome: brain-gut interaction, visceral sensitivity,
role of 5HT and related peptides, sleep disorders, stress
factors. |
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| 7) Postinfective
gut dysfunction |
| a) |
management
of persistent postinfective diarrhoea |
| b) |
effects
of H pylori infection on gastric functions |
| c) |
inflammatory
mechanisms, cytokines, mast cells in postinfective irritable
bowel syndrome, inflammatory bowel disease |
| d) |
bacterial
flora and colonic fermentation |
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| The Helicobacter
pylori Research Group is a multi-disciplinary multi-departmental
programme with the main aims of identifying molecular mechanisms
of Helicobacter pylori, and improvement of treatment.
The group is registered as a Faculty Research Programme in the
Medical Faculty of the National University of Singapore. |
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| The group
comprises: |
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| Programme
Coordinator : |
Assoc
Prof Yeoh Khay Guan |
| Assoc
Prof Ho Bow |
Dept
of Microbiology |
| Assoc
Prof Lim Seng Gee |
Dept
of Medicine |
| Assoc
Prof Gwee Kok Ann |
Dept
of Pharmacology |
| Assoc
Prof Quak Seng Hock |
Dept
of Paediatrics |
| Assoc
Prof Teh Ming |
Dept
of Pathology |
| Prof
Aileen Wee |
Dept
of Pathology |
| Dr
Marion Aw |
Dept
of Paediatrics |
| Assoc
Prof Ho Khek Yu |
Dept
of Medicine |
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